Detailed information of TA system TA280196

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3890095..3891784
• Replicon: chromosome
• Accession: NZ_CP124424
• Organism: Escherichia coli strain AVS0247

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJB03_RS18770
• Protein ID: WP_000365807.1
• Coordinates: 3890864..3891784 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJB03_RS18765
• Protein ID: WP_001295795.1
• Coordinates: 3890095..3890877 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJB03_RS18760 (3886713)	3886713..3889811	-	3099	WP_000673070.1	type I restriction endonuclease	-
QJB03_RS18765 (3890095)	3890095..3890877	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJB03_RS18770 (3890864)	3890864..3891784	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJB03_RS18775 (3891949)	3891949..3892725	-	777	WP_000171155.1	site-specific integrase	-
QJB03_RS18780 (3892933)	3892933..3893268	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJB03_RS18785 (3893495)	3893495..3893653	-	159	Protein_3668	integrase	-
QJB03_RS18790 (3893702)	3893702..3893887	+	186	WP_000146240.1	hypothetical protein	-
QJB03_RS18795 (3894102)	3894102..3894716	+	615	WP_001019923.1	YagU family protein	-
QJB03_RS18800 (3894787)	3894787..3894953	+	167	Protein_3671	tail fiber assembly protein	-
QJB03_RS18805 (3894965)	3894965..3895294	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJB03_RS18810 (3895601)	3895601..3896311	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR	3883845..3909230	25385

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280196 WP_000365807.1 NZ_CP124424:3890864-3891784 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280196 WP_001295795.1 NZ_CP124424:3890095-3890877 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0