Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 168467..169038 Replicon chromosome
Accession NC_018089
Organism Streptococcus mutans GS-5

Toxin (Protein)


Gene name mazF Uniprot ID A0A829BNU4
Locus tag SMUGS5_RS00820 Protein ID WP_002275484.1
Coordinates 168706..169038 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2J9QC51
Locus tag SMUGS5_RS00815 Protein ID WP_002264866.1
Coordinates 168467..168712 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMUGS5_RS00780 163975..164721 + 747 WP_014834793.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
SMUGS5_RS00785 164745..165605 + 861 WP_002273088.1 DegV family protein -
SMUGS5_RS00790 165737..166252 + 516 WP_002264864.1 hypothetical protein -
SMUGS5_RS00795 166252..166698 + 447 WP_014834794.1 hypothetical protein -
SMUGS5_RS00800 166695..166889 + 195 WP_002262994.1 helix-turn-helix transcriptional regulator -
SMUGS5_RS00805 167282..167728 + 447 WP_002262993.1 50S ribosomal protein L13 -
SMUGS5_RS00810 167753..168145 + 393 WP_002262992.1 30S ribosomal protein S9 -
SMUGS5_RS00815 168467..168712 + 246 WP_002264866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SMUGS5_RS00820 168706..169038 + 333 WP_002275484.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SMUGS5_RS00825 169236..170027 - 792 WP_014834795.1 nucleotidyltransferase domain-containing protein -
SMUGS5_RS10525 170192..170545 + 354 Protein_148 transposase family protein -
SMUGS5_RS00830 170727..171947 + 1221 WP_002270688.1 PTS sugar transporter subunit IIC -
SMUGS5_RS00835 171925..172773 + 849 WP_002265112.1 alpha/beta hydrolase -
SMUGS5_RS00840 172915..173517 + 603 WP_014834796.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 170192..170320 128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

Antitoxin PemI-like

(1-81)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12650.53 Da        Isoelectric Point: 6.4634

>T28019 WP_002275484.1 NC_018089:168706-169038 [Streptococcus mutans GS-5]
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIGIFAPISNTKRDYPFYVPLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Download         Length: 333 bp

>T28019 NC_018089:168706-169038 [Streptococcus mutans GS-5]
ATGGTAACCATCAAGCAAGGGTCAATTATCAAAATTAACTTGGATCCCAAACAAGGACATGAACAAAAAGGGTATCGTCC
GTACATTTGTCTAAATCATAGTATCGTAACCAAGTATTCTAATATTGGTATTTTTGCGCCAATTAGCAATACCAAGCGTG
ATTACCCTTTTTATGTTCCCCTAGAAGGAACAGAATCCACAGGGAAAGTATTATTAGACCAACTGGTTACAATTGATTTT
AATGCTAGAGATTATCGTTATGTGGAGGATATTCAGGAAGACTTATTAGATGAACTTTTAGCTAGGGTCAAAGTGCTATT
TGAAAAAGGATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9255.55 Da        Isoelectric Point: 4.3021

>AT28019 WP_002264866.1 NC_018089:168467-168712 [Streptococcus mutans GS-5]
MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNVPELTVEDLFKDYQGEPVNVTPVLFESVGNEQ
W

Download         Length: 246 bp

>AT28019 NC_018089:168467-168712 [Streptococcus mutans GS-5]
ATGCAACTAGTCATCAATAAATGGGGAAATAGCTCCGCTATTCGTTTGCCAAAACAATTGGTACAAGAATTACAATTACA
AACAAATGATGTCTTAGACTATAAGGTATCAGGGAATAAAATTATCCTAGAAAAAGTGAATAATGTCCCTGAATTAACTG
TAGAAGATCTGTTTAAAGATTATCAAGGTGAACCTGTCAATGTTACCCCAGTTCTATTTGAAAGTGTGGGAAATGAACAA
TGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829BNU4

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9QC51

References