Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2364408..2365208 Replicon chromosome
Accession NZ_CP124424
Organism Escherichia coli strain AVS0247

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJB03_RS11525 Protein ID WP_000342452.1
Coordinates 2364408..2364935 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJB03_RS11530 Protein ID WP_001277107.1
Coordinates 2364942..2365208 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB03_RS11500 (2359484) 2359484..2360251 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJB03_RS11505 (2360248) 2360248..2361525 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJB03_RS11510 (2361522) 2361522..2362448 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJB03_RS11515 (2362496) 2362496..2363605 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJB03_RS11520 (2364028) 2364028..2364411 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJB03_RS11525 (2364408) 2364408..2364935 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJB03_RS11530 (2364942) 2364942..2365208 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJB03_RS11535 (2365357) 2365357..2366460 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJB03_RS11540 (2366731) 2366731..2367585 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJB03_RS11545 (2367830) 2367830..2368888 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJB03_RS11550 (2368881) 2368881..2369549 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T280189 WP_000342452.1 NZ_CP124424:c2364935-2364408 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT280189 WP_001277107.1 NZ_CP124424:c2365208-2364942 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References