Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | SmuAT/- |
| Location | 165737..166698 | Replicon | chromosome |
| Accession | NC_018089 | ||
| Organism | Streptococcus mutans GS-5 | ||
Toxin (Protein)
| Gene name | smuT | Uniprot ID | - |
| Locus tag | SMUGS5_RS00790 | Protein ID | WP_002264864.1 |
| Coordinates | 165737..166252 (+) | Length | 172 a.a. |
Antitoxin (Protein)
| Gene name | smuA | Uniprot ID | - |
| Locus tag | SMUGS5_RS00795 | Protein ID | WP_014834794.1 |
| Coordinates | 166252..166698 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SMUGS5_RS00765 | 161154..161891 | + | 738 | WP_002263001.1 | MerR family transcriptional regulator | - |
| SMUGS5_RS00770 | 161927..162919 | - | 993 | WP_002267808.1 | BtrH N-terminal domain-containing protein | - |
| SMUGS5_RS00775 | 163108..163662 | - | 555 | WP_002264861.1 | PadR family transcriptional regulator | - |
| SMUGS5_RS00780 | 163975..164721 | + | 747 | WP_014834793.1 | 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB | - |
| SMUGS5_RS00785 | 164745..165605 | + | 861 | WP_002273088.1 | DegV family protein | - |
| SMUGS5_RS00790 | 165737..166252 | + | 516 | WP_002264864.1 | hypothetical protein | Toxin |
| SMUGS5_RS00795 | 166252..166698 | + | 447 | WP_014834794.1 | hypothetical protein | Antitoxin |
| SMUGS5_RS00800 | 166695..166889 | + | 195 | WP_002262994.1 | helix-turn-helix transcriptional regulator | - |
| SMUGS5_RS00805 | 167282..167728 | + | 447 | WP_002262993.1 | 50S ribosomal protein L13 | - |
| SMUGS5_RS00810 | 167753..168145 | + | 393 | WP_002262992.1 | 30S ribosomal protein S9 | - |
| SMUGS5_RS00815 | 168467..168712 | + | 246 | WP_002264866.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| SMUGS5_RS00820 | 168706..169038 | + | 333 | WP_002275484.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| SMUGS5_RS00825 | 169236..170027 | - | 792 | WP_014834795.1 | nucleotidyltransferase domain-containing protein | - |
| SMUGS5_RS10525 | 170192..170545 | + | 354 | Protein_148 | transposase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 170192..170320 | 128 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 172 a.a. Molecular weight: 19540.17 Da Isoelectric Point: 9.8779
>T28018 WP_002264864.1 NC_018089:165737-166252 [Streptococcus mutans GS-5]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKRFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKRFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK
Download Length: 516 bp
>T28018 NC_018089:165737-166252 [Streptococcus mutans GS-5]
ATGTTTGACCTTGTTGTTAATTTAATTTTATTGGTTATTGTGATAGGTGGATTTGTCTTCTTAAGATTCTATGCGGATAA
GAAAGGCAAGCGAGAATACGATGAACGCCAGTTACTTATGCAAAAGAAAGCTTATACCAATGCGGCTTGGGTTGTTATGG
GTTTCAATCTTGTTCTTGTGATATGGGGTGAAGTGTTAGCAAAATATATCTCGCTATCCTTTGCAGGTACTGCCAATCTC
TTTCTTATCGTAGGCGTCTTTGTCTGCAGCAGTATCTTAAACGATGCTTATTTCACAGCAAGAAAAAACAAAAGATTCCT
CTATGTGTATGCCGTTATTATTGCTATTCAAATTTTCACTGTTTATCAAAATTGGAGTCAAGGCAGCTTTGGTCATGACG
GACATATTTATCTAACAGGAGAAAAAGCAATGAGTTTATTGTTTATCTTGACTTTTGCTGTCATTTTTCTAGTAACTGCT
TATAAAACGATTCAGGATAAGAGAGAGGGAAAGTGA
ATGTTTGACCTTGTTGTTAATTTAATTTTATTGGTTATTGTGATAGGTGGATTTGTCTTCTTAAGATTCTATGCGGATAA
GAAAGGCAAGCGAGAATACGATGAACGCCAGTTACTTATGCAAAAGAAAGCTTATACCAATGCGGCTTGGGTTGTTATGG
GTTTCAATCTTGTTCTTGTGATATGGGGTGAAGTGTTAGCAAAATATATCTCGCTATCCTTTGCAGGTACTGCCAATCTC
TTTCTTATCGTAGGCGTCTTTGTCTGCAGCAGTATCTTAAACGATGCTTATTTCACAGCAAGAAAAAACAAAAGATTCCT
CTATGTGTATGCCGTTATTATTGCTATTCAAATTTTCACTGTTTATCAAAATTGGAGTCAAGGCAGCTTTGGTCATGACG
GACATATTTATCTAACAGGAGAAAAAGCAATGAGTTTATTGTTTATCTTGACTTTTGCTGTCATTTTTCTAGTAACTGCT
TATAAAACGATTCAGGATAAGAGAGAGGGAAAGTGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16945.21 Da Isoelectric Point: 9.0938
>AT28018 WP_014834794.1 NC_018089:166252-166698 [Streptococcus mutans GS-5]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGCLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASVIYRHYLDKKEADK
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGCLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASVIYRHYLDKKEADK
Download Length: 447 bp
>AT28018 NC_018089:166252-166698 [Streptococcus mutans GS-5]
ATGAAAATGGAAAAGTCAAATAAACAAGTCATTTACGATGAACGTCAGCAGCAAATTCAACTTAAAAGTTATAGTCTTTC
ATTTTGGTTTGTTATGTTTATACTCTATTTTGCAACTTTTGGAAAGACTGATTTGTTGCTTAATATCGCTTTTTGGGGAG
GACTTGTTCTTAATTTTTGCTACAGTACTCTAAGAGGTGTTGGTCCTTTTGTTGATCCACGTTTTGGAAAAATTGCAAAA
ATCGGTTGTTTGGCCGCTGTTCCCCTTATTTTTTTGGGAATGCTAGTCTTTCTTGTTGCTATCATAATGTCTATTCTAGA
ACATGATAGTTTAAGAGAATCTATCACAAAATGCTCCTACTTAGGCTTATCTGGTTTTTGGCTAATTTGTATGGGAGCAA
GTGTCATCTACCGTCATTATCTTGATAAGAAAGAAGCAGACAAATGA
ATGAAAATGGAAAAGTCAAATAAACAAGTCATTTACGATGAACGTCAGCAGCAAATTCAACTTAAAAGTTATAGTCTTTC
ATTTTGGTTTGTTATGTTTATACTCTATTTTGCAACTTTTGGAAAGACTGATTTGTTGCTTAATATCGCTTTTTGGGGAG
GACTTGTTCTTAATTTTTGCTACAGTACTCTAAGAGGTGTTGGTCCTTTTGTTGATCCACGTTTTGGAAAAATTGCAAAA
ATCGGTTGTTTGGCCGCTGTTCCCCTTATTTTTTTGGGAATGCTAGTCTTTCTTGTTGCTATCATAATGTCTATTCTAGA
ACATGATAGTTTAAGAGAATCTATCACAAAATGCTCCTACTTAGGCTTATCTGGTTTTTGGCTAATTTGTATGGGAGCAA
GTGTCATCTACCGTCATTATCTTGATAAGAAAGAAGCAGACAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|