28018

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) SmuAT/-
Location 165737..166698 Replicon chromosome
Accession NC_018089
Organism Streptococcus mutans GS-5

Toxin (Protein)


Gene name smuT Uniprot ID -
Locus tag SMUGS5_RS00790 Protein ID WP_002264864.1
Coordinates 165737..166252 (+) Length 172 a.a.

Antitoxin (Protein)


Gene name smuA Uniprot ID -
Locus tag SMUGS5_RS00795 Protein ID WP_014834794.1
Coordinates 166252..166698 (+) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMUGS5_RS00765 161154..161891 + 738 WP_002263001.1 MerR family transcriptional regulator -
SMUGS5_RS00770 161927..162919 - 993 WP_002267808.1 BtrH N-terminal domain-containing protein -
SMUGS5_RS00775 163108..163662 - 555 WP_002264861.1 PadR family transcriptional regulator -
SMUGS5_RS00780 163975..164721 + 747 WP_014834793.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
SMUGS5_RS00785 164745..165605 + 861 WP_002273088.1 DegV family protein -
SMUGS5_RS00790 165737..166252 + 516 WP_002264864.1 hypothetical protein Toxin
SMUGS5_RS00795 166252..166698 + 447 WP_014834794.1 hypothetical protein Antitoxin
SMUGS5_RS00800 166695..166889 + 195 WP_002262994.1 helix-turn-helix transcriptional regulator -
SMUGS5_RS00805 167282..167728 + 447 WP_002262993.1 50S ribosomal protein L13 -
SMUGS5_RS00810 167753..168145 + 393 WP_002262992.1 30S ribosomal protein S9 -
SMUGS5_RS00815 168467..168712 + 246 WP_002264866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
SMUGS5_RS00820 168706..169038 + 333 WP_002275484.1 type II toxin-antitoxin system PemK/MazF family toxin -
SMUGS5_RS00825 169236..170027 - 792 WP_014834795.1 nucleotidyltransferase domain-containing protein -
SMUGS5_RS10525 170192..170545 + 354 Protein_148 transposase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 170192..170320 128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-238)

Antitoxin

(1-56)


Sequences


Toxin        


Download         Length: 172 a.a.        Molecular weight: 19540.17 Da        Isoelectric Point: 9.8779

>T28018 WP_002264864.1 NC_018089:165737-166252 [Streptococcus mutans GS-5]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKRFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK

Download         Length: 516 bp

>T28018 NC_018089:165737-166252 [Streptococcus mutans GS-5]
ATGTTTGACCTTGTTGTTAATTTAATTTTATTGGTTATTGTGATAGGTGGATTTGTCTTCTTAAGATTCTATGCGGATAA
GAAAGGCAAGCGAGAATACGATGAACGCCAGTTACTTATGCAAAAGAAAGCTTATACCAATGCGGCTTGGGTTGTTATGG
GTTTCAATCTTGTTCTTGTGATATGGGGTGAAGTGTTAGCAAAATATATCTCGCTATCCTTTGCAGGTACTGCCAATCTC
TTTCTTATCGTAGGCGTCTTTGTCTGCAGCAGTATCTTAAACGATGCTTATTTCACAGCAAGAAAAAACAAAAGATTCCT
CTATGTGTATGCCGTTATTATTGCTATTCAAATTTTCACTGTTTATCAAAATTGGAGTCAAGGCAGCTTTGGTCATGACG
GACATATTTATCTAACAGGAGAAAAAGCAATGAGTTTATTGTTTATCTTGACTTTTGCTGTCATTTTTCTAGTAACTGCT
TATAAAACGATTCAGGATAAGAGAGAGGGAAAGTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16945.21 Da        Isoelectric Point: 9.0938

>AT28018 WP_014834794.1 NC_018089:166252-166698 [Streptococcus mutans GS-5]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGCLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASVIYRHYLDKKEADK

Download         Length: 447 bp

>AT28018 NC_018089:166252-166698 [Streptococcus mutans GS-5]
ATGAAAATGGAAAAGTCAAATAAACAAGTCATTTACGATGAACGTCAGCAGCAAATTCAACTTAAAAGTTATAGTCTTTC
ATTTTGGTTTGTTATGTTTATACTCTATTTTGCAACTTTTGGAAAGACTGATTTGTTGCTTAATATCGCTTTTTGGGGAG
GACTTGTTCTTAATTTTTGCTACAGTACTCTAAGAGGTGTTGGTCCTTTTGTTGATCCACGTTTTGGAAAAATTGCAAAA
ATCGGTTGTTTGGCCGCTGTTCCCCTTATTTTTTTGGGAATGCTAGTCTTTCTTGTTGCTATCATAATGTCTATTCTAGA
ACATGATAGTTTAAGAGAATCTATCACAAAATGCTCCTACTTAGGCTTATCTGGTTTTTGGCTAATTTGTATGGGAGCAA
GTGTCATCTACCGTCATTATCTTGATAAGAAAGAAGCAGACAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References