Detailed information of TA system TA280169

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4378294..4379983
• Replicon: chromosome
• Accession: NZ_CP124420
• Organism: Escherichia coli strain AVS0155

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP63_RS21405
• Protein ID: WP_000365807.1
• Coordinates: 4379063..4379983 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP63_RS21400
• Protein ID: WP_001295795.1
• Coordinates: 4378294..4379076 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP63_RS21395 (4374912)	4374912..4378010	-	3099	WP_000673070.1	type I restriction endonuclease	-
QJP63_RS21400 (4378294)	4378294..4379076	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP63_RS21405 (4379063)	4379063..4379983	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP63_RS21410 (4380148)	4380148..4380924	-	777	WP_000171155.1	site-specific integrase	-
QJP63_RS21415 (4381132)	4381132..4381467	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP63_RS21420 (4381694)	4381694..4381852	-	159	Protein_4190	integrase	-
QJP63_RS21425 (4381901)	4381901..4382086	+	186	WP_000146240.1	hypothetical protein	-
QJP63_RS21430 (4382301)	4382301..4382915	+	615	WP_001019923.1	YagU family protein	-
QJP63_RS21435 (4382986)	4382986..4383152	+	167	Protein_4193	tail fiber assembly protein	-
QJP63_RS21440 (4383164)	4383164..4383493	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP63_RS21445 (4383800)	4383800..4384510	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	4372044..4420199	48155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280169 WP_000365807.1 NZ_CP124420:4379063-4379983 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280169 WP_001295795.1 NZ_CP124420:4378294-4379076 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0