Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3820146..3820741 Replicon chromosome
Accession NZ_CP124420
Organism Escherichia coli strain AVS0155

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QJP63_RS18670 Protein ID WP_000239579.1
Coordinates 3820391..3820741 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QJP63_RS18665 Protein ID WP_001223208.1
Coordinates 3820146..3820397 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP63_RS18655 (3815811) 3815811..3819590 + 3780 WP_000060945.1 autotransporter assembly complex protein TamB -
QJP63_RS18660 (3819593) 3819593..3819934 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QJP63_RS18665 (3820146) 3820146..3820397 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QJP63_RS18670 (3820391) 3820391..3820741 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QJP63_RS18675 (3820821) 3820821..3821351 - 531 WP_000055075.1 inorganic diphosphatase -
QJP63_RS18680 (3821661) 3821661..3822617 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QJP63_RS18685 (3822757) 3822757..3824259 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
QJP63_RS18690 (3824273) 3824273..3825295 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T280165 WP_000239579.1 NZ_CP124420:3820391-3820741 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT280165 WP_001223208.1 NZ_CP124420:3820146-3820397 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References