Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3715708..3716205 Replicon chromosome
Accession NZ_CP124420
Organism Escherichia coli strain AVS0155

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QJP63_RS18135 Protein ID WP_001173343.1
Coordinates 3716032..3716205 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag QJP63_RS18130 Protein ID WP_001312331.1
Coordinates 3715708..3716004 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP63_RS18120 (3711065) 3711065..3714994 + 3930 WP_001080129.1 autotransporter outer membrane beta-barrel domain-containing protein -
QJP63_RS18125 (3715208) 3715208..3715480 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
QJP63_RS18130 (3715708) 3715708..3716004 + 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QJP63_RS18135 (3716032) 3716032..3716205 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QJP63_RS18140 (3716324) 3716324..3717841 - 1518 WP_000003806.1 lysine--tRNA ligase -
QJP63_RS18145 (3718078) 3718078..3719535 - 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3700117..3725058 24941


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T280164 WP_001173343.1 NZ_CP124420:3716032-3716205 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT280164 WP_001312331.1 NZ_CP124420:3715708-3716004 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References