Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2887618..2888418 Replicon chromosome
Accession NZ_CP124420
Organism Escherichia coli strain AVS0155

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP63_RS14360 Protein ID WP_000342452.1
Coordinates 2887618..2888145 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP63_RS14365 Protein ID WP_001277107.1
Coordinates 2888152..2888418 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP63_RS14335 (2882694) 2882694..2883461 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJP63_RS14340 (2883458) 2883458..2884735 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP63_RS14345 (2884732) 2884732..2885658 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP63_RS14350 (2885706) 2885706..2886815 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP63_RS14355 (2887238) 2887238..2887621 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP63_RS14360 (2887618) 2887618..2888145 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP63_RS14365 (2888152) 2888152..2888418 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP63_RS14370 (2888567) 2888567..2889670 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP63_RS14375 (2889941) 2889941..2890795 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP63_RS14380 (2891040) 2891040..2892098 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJP63_RS14385 (2892091) 2892091..2892759 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T280162 WP_000342452.1 NZ_CP124420:c2888145-2887618 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT280162 WP_001277107.1 NZ_CP124420:c2888418-2888152 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References