Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4049379..4049997 Replicon chromosome
Accession NZ_CP124415
Organism Escherichia coli strain AVS0223

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP60_RS19440 Protein ID WP_001291435.1
Coordinates 4049379..4049597 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP60_RS19445 Protein ID WP_000344800.1
Coordinates 4049623..4049997 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP60_RS19405 (4044666) 4044666..4045238 + 573 WP_000779831.1 YbaY family lipoprotein -
QJP60_RS19410 (4045269) 4045269..4045580 - 312 WP_000409908.1 MGMT family protein -
QJP60_RS19420 (4045959) 4045959..4046312 + 354 WP_000878135.1 DUF1428 family protein -
QJP60_RS19425 (4046354) 4046354..4047904 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP60_RS19430 (4048068) 4048068..4048538 - 471 WP_000136192.1 YlaC family protein -
QJP60_RS19435 (4048654) 4048654..4049205 - 552 WP_000102539.1 maltose O-acetyltransferase -
QJP60_RS19440 (4049379) 4049379..4049597 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP60_RS19445 (4049623) 4049623..4049997 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP60_RS19450 (4050543) 4050543..4053692 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP60_RS19455 (4053715) 4053715..4054908 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280131 WP_001291435.1 NZ_CP124415:c4049597-4049379 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280131 WP_000344800.1 NZ_CP124415:c4049997-4049623 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References