Detailed information of TA system TA280130

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3864582..3866271
• Replicon: chromosome
• Accession: NZ_CP124415
• Organism: Escherichia coli strain AVS0223

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP60_RS18575
• Protein ID: WP_000365807.1
• Coordinates: 3865351..3866271 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP60_RS18570
• Protein ID: WP_001295795.1
• Coordinates: 3864582..3865364 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP60_RS18565 (3861200)	3861200..3864298	-	3099	WP_000673070.1	type I restriction endonuclease	-
QJP60_RS18570 (3864582)	3864582..3865364	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP60_RS18575 (3865351)	3865351..3866271	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP60_RS18580 (3866436)	3866436..3867212	-	777	WP_000171155.1	site-specific integrase	-
QJP60_RS18585 (3867420)	3867420..3867755	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP60_RS18590 (3867982)	3867982..3868140	-	159	Protein_3632	integrase	-
QJP60_RS18595 (3868189)	3868189..3868374	+	186	WP_000146240.1	hypothetical protein	-
QJP60_RS18600 (3868589)	3868589..3869203	+	615	WP_001019923.1	YagU family protein	-
QJP60_RS18605 (3869274)	3869274..3869440	+	167	Protein_3635	tail fiber assembly protein	-
QJP60_RS18610 (3869452)	3869452..3869781	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP60_RS18615 (3870088)	3870088..3870798	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	3858332..3906216	47884

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280130 WP_000365807.1 NZ_CP124415:3865351-3866271 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280130 WP_001295795.1 NZ_CP124415:3864582-3865364 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0