Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3325513..3326108 Replicon chromosome
Accession NZ_CP124415
Organism Escherichia coli strain AVS0223

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QJP60_RS15955 Protein ID WP_000239579.1
Coordinates 3325758..3326108 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QJP60_RS15950 Protein ID WP_001223208.1
Coordinates 3325513..3325764 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP60_RS15940 (3321178) 3321178..3324957 + 3780 WP_000060945.1 autotransporter assembly complex protein TamB -
QJP60_RS15945 (3324960) 3324960..3325301 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QJP60_RS15950 (3325513) 3325513..3325764 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QJP60_RS15955 (3325758) 3325758..3326108 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QJP60_RS15960 (3326188) 3326188..3326718 - 531 WP_000055075.1 inorganic diphosphatase -
QJP60_RS15965 (3327028) 3327028..3327984 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QJP60_RS15970 (3328124) 3328124..3329626 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
QJP60_RS15975 (3329640) 3329640..3330662 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T280126 WP_000239579.1 NZ_CP124415:3325758-3326108 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT280126 WP_001223208.1 NZ_CP124415:3325513-3325764 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References