Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2393304..2394104 Replicon chromosome
Accession NZ_CP124415
Organism Escherichia coli strain AVS0223

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP60_RS11645 Protein ID WP_000342452.1
Coordinates 2393304..2393831 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP60_RS11650 Protein ID WP_001277107.1
Coordinates 2393838..2394104 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP60_RS11620 (2388380) 2388380..2389147 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJP60_RS11625 (2389144) 2389144..2390421 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP60_RS11630 (2390418) 2390418..2391344 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP60_RS11635 (2391392) 2391392..2392501 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP60_RS11640 (2392924) 2392924..2393307 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP60_RS11645 (2393304) 2393304..2393831 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP60_RS11650 (2393838) 2393838..2394104 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP60_RS11655 (2394253) 2394253..2395356 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP60_RS11660 (2395627) 2395627..2396481 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP60_RS11665 (2396726) 2396726..2397784 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJP60_RS11670 (2397777) 2397777..2398445 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T280123 WP_000342452.1 NZ_CP124415:c2393831-2393304 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT280123 WP_001277107.1 NZ_CP124415:c2394104-2393838 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References