Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1715448..1716102 Replicon chromosome
Accession NZ_CP124415
Organism Escherichia coli strain AVS0223

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJP60_RS08215 Protein ID WP_000244765.1
Coordinates 1715448..1715855 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJP60_RS08220 Protein ID WP_000354050.1
Coordinates 1715836..1716102 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP60_RS08195 (1711405) 1711405..1713138 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
QJP60_RS08200 (1713144) 1713144..1713854 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJP60_RS08205 (1713879) 1713879..1714775 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJP60_RS08210 (1714887) 1714887..1715408 + 522 WP_001055874.1 flavodoxin FldB -
QJP60_RS08215 (1715448) 1715448..1715855 - 408 WP_000244765.1 protein YgfX Toxin
QJP60_RS08220 (1715836) 1715836..1716102 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJP60_RS08225 (1716345) 1716345..1717325 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
QJP60_RS08230 (1717402) 1717402..1718061 - 660 WP_000250275.1 hemolysin III family protein -
QJP60_RS08235 (1718225) 1718225..1718536 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJP60_RS08240 (1718581) 1718581..1720014 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T280119 WP_000244765.1 NZ_CP124415:c1715855-1715448 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT280119 WP_000354050.1 NZ_CP124415:c1716102-1715836 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References