Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142708..143213 Replicon chromosome
Accession NC_018080
Organism Pseudomonas aeruginosa DK2

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PADK2_RS00635 Protein ID WP_003083773.1
Coordinates 142708..142989 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PADK2_RS00640 Protein ID WP_003083775.1
Coordinates 142986..143213 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PADK2_RS00610 137959..139308 + 1350 WP_073651543.1 C4-dicarboxylate transporter DctA -
PADK2_RS00615 139357..140043 + 687 WP_014833853.1 FadR family transcriptional regulator -
PADK2_RS00620 140144..140878 + 735 WP_003117208.1 GntR family transcriptional regulator -
PADK2_RS00625 141082..141468 + 387 WP_014602345.1 aegerolysin family protein -
PADK2_RS00630 141500..142408 - 909 WP_003083769.1 LysR family transcriptional regulator -
PADK2_RS00635 142708..142989 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PADK2_RS00640 142986..143213 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PADK2_RS00645 143389..144009 - 621 WP_003101226.1 hypothetical protein -
PADK2_RS00650 144110..144610 + 501 WP_003101228.1 LEA type 2 family protein -
PADK2_RS00655 144683..145024 + 342 WP_003101229.1 alkylphosphonate utilization protein -
PADK2_RS00660 145106..146533 - 1428 WP_003117210.1 GABA permease -
PADK2_RS00665 146702..148195 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T28011 WP_003083773.1 NC_018080:c142989-142708 [Pseudomonas aeruginosa DK2]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T28011 NC_018080:c142989-142708 [Pseudomonas aeruginosa DK2]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT28011 WP_003083775.1 NC_018080:c143213-142986 [Pseudomonas aeruginosa DK2]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT28011 NC_018080:c143213-142986 [Pseudomonas aeruginosa DK2]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References