Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4025393..4026053 Replicon chromosome
Accession NC_018079
Organism Enterobacter cloacae subsp. dissolvens SDM

Toxin (Protein)


Gene name cptA Uniprot ID A0A3R9A2Z6
Locus tag A3UG_RS18880 Protein ID WP_014833181.1
Coordinates 4025393..4025806 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A5E1AG01
Locus tag A3UG_RS18885 Protein ID WP_013098615.1
Coordinates 4025787..4026053 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3UG_RS18860 4021386..4023119 - 1734 WP_014833178.1 single-stranded-DNA-specific exonuclease RecJ -
A3UG_RS18865 4023125..4023838 - 714 WP_013098611.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A3UG_RS18870 4023867..4024763 - 897 WP_014833179.1 site-specific tyrosine recombinase XerD -
A3UG_RS18875 4024865..4025386 + 522 WP_014833180.1 flavodoxin FldB -
A3UG_RS18880 4025393..4025806 - 414 WP_014833181.1 protein YgfX Toxin
A3UG_RS18885 4025787..4026053 - 267 WP_013098615.1 FAD assembly factor SdhE Antitoxin
A3UG_RS18890 4026348..4027328 + 981 WP_014833182.1 tRNA-modifying protein YgfZ -
A3UG_RS18895 4027438..4028097 - 660 WP_003863433.1 hemolysin III family protein -
A3UG_RS18905 4028363..4029094 + 732 WP_014833183.1 MurR/RpiR family transcriptional regulator -
A3UG_RS18910 4029211..4030644 + 1434 WP_014833184.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16206.14 Da        Isoelectric Point: 10.7596

>T28010 WP_014833181.1 NC_018079:c4025806-4025393 [Enterobacter cloacae subsp. dissolvens SDM]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGQ
EWDILGMPWMLSSGMMLRLRQVGGGKCQHLWLAADSMDIAEWRDLRRMILQQQPTQE

Download         Length: 414 bp

>T28010 NC_018079:c4025806-4025393 [Enterobacter cloacae subsp. dissolvens SDM]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCATGGCGCTCGCAGTGGATGTCGTTATTGCTCCACGGCCTGGTCGCGGC
CTTTGTTTTACTGATGCCGTGGCCGCTTAGCTATACGCCTCTGTGGCTGTTGTTGTTGTCGTTCGTCGTTTTTGACAGCG
TGCGCAGCCAGCGCCGGATCAATGCCCGCCAGGGTGAGATTAAATTACTGATGGACTCCCGCCTGCGCTGGCAGGGGCAG
GAGTGGGATATCCTCGGTATGCCCTGGATGCTCAGTTCCGGCATGATGCTACGGTTACGCCAGGTGGGCGGCGGTAAGTG
CCAGCATCTGTGGCTGGCCGCCGACAGTATGGATATTGCGGAGTGGCGGGATCTGCGCCGGATGATATTGCAGCAGCAAC
CGACGCAGGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1456

>AT28010 WP_013098615.1 NC_018079:c4026053-4025787 [Enterobacter cloacae subsp. dissolvens SDM]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDEDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT28010 NC_018079:c4026053-4025787 [Enterobacter cloacae subsp. dissolvens SDM]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGACGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGAGGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9A2Z6

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AG01

References