Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3228020..3228517 Replicon chromosome
Accession NZ_CP124410
Organism Escherichia coli strain AVS0543

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QJP61_RS15485 Protein ID WP_001173343.1
Coordinates 3228344..3228517 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag QJP61_RS15480 Protein ID WP_001312331.1
Coordinates 3228020..3228316 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP61_RS15470 (3223377) 3223377..3227306 + 3930 WP_001080129.1 autotransporter outer membrane beta-barrel domain-containing protein -
QJP61_RS15475 (3227520) 3227520..3227792 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
QJP61_RS15480 (3228020) 3228020..3228316 + 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QJP61_RS15485 (3228344) 3228344..3228517 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QJP61_RS15490 (3228636) 3228636..3230153 - 1518 WP_000003806.1 lysine--tRNA ligase -
QJP61_RS15495 (3230390) 3230390..3231847 - 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3212430..3237370 24940


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T280091 WP_001173343.1 NZ_CP124410:3228344-3228517 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT280091 WP_001312331.1 NZ_CP124410:3228020-3228316 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References