Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2397105..2397905 Replicon chromosome
Accession NZ_CP124410
Organism Escherichia coli strain AVS0543

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP61_RS11685 Protein ID WP_000342452.1
Coordinates 2397105..2397632 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP61_RS11690 Protein ID WP_001277107.1
Coordinates 2397639..2397905 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP61_RS11660 (2392181) 2392181..2392948 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJP61_RS11665 (2392945) 2392945..2394222 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP61_RS11670 (2394219) 2394219..2395145 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP61_RS11675 (2395193) 2395193..2396302 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP61_RS11680 (2396725) 2396725..2397108 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP61_RS11685 (2397105) 2397105..2397632 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP61_RS11690 (2397639) 2397639..2397905 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP61_RS11695 (2398054) 2398054..2399157 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP61_RS11700 (2399428) 2399428..2400282 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP61_RS11705 (2400527) 2400527..2401585 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJP61_RS11710 (2401578) 2401578..2402246 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T280089 WP_000342452.1 NZ_CP124410:c2397632-2397105 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT280089 WP_001277107.1 NZ_CP124410:c2397905-2397639 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References