Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1719336..1719990 Replicon chromosome
Accession NZ_CP124410
Organism Escherichia coli strain AVS0543

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJP61_RS08245 Protein ID WP_000244765.1
Coordinates 1719336..1719743 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJP61_RS08250 Protein ID WP_000354050.1
Coordinates 1719724..1719990 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP61_RS08225 (1715293) 1715293..1717026 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
QJP61_RS08230 (1717032) 1717032..1717742 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJP61_RS08235 (1717767) 1717767..1718663 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJP61_RS08240 (1718775) 1718775..1719296 + 522 WP_001055874.1 flavodoxin FldB -
QJP61_RS08245 (1719336) 1719336..1719743 - 408 WP_000244765.1 protein YgfX Toxin
QJP61_RS08250 (1719724) 1719724..1719990 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJP61_RS08255 (1720233) 1720233..1721213 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
QJP61_RS08260 (1721290) 1721290..1721949 - 660 WP_000250275.1 hemolysin III family protein -
QJP61_RS08265 (1722113) 1722113..1722424 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJP61_RS08270 (1722469) 1722469..1723902 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T280085 WP_000244765.1 NZ_CP124410:c1719743-1719336 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT280085 WP_000354050.1 NZ_CP124410:c1719990-1719724 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References