Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3994226..3994844 Replicon chromosome
Accession NZ_CP124405
Organism Escherichia coli strain AVS0935

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJB05_RS19145 Protein ID WP_001291435.1
Coordinates 3994226..3994444 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJB05_RS19150 Protein ID WP_000344800.1
Coordinates 3994470..3994844 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB05_RS19110 (3989513) 3989513..3990085 + 573 WP_000779831.1 YbaY family lipoprotein -
QJB05_RS19115 (3990116) 3990116..3990427 - 312 WP_000409908.1 MGMT family protein -
QJB05_RS19125 (3990806) 3990806..3991159 + 354 WP_000878135.1 DUF1428 family protein -
QJB05_RS19130 (3991201) 3991201..3992751 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJB05_RS19135 (3992915) 3992915..3993385 - 471 WP_000136192.1 YlaC family protein -
QJB05_RS19140 (3993501) 3993501..3994052 - 552 WP_000102539.1 maltose O-acetyltransferase -
QJB05_RS19145 (3994226) 3994226..3994444 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QJB05_RS19150 (3994470) 3994470..3994844 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJB05_RS19155 (3995390) 3995390..3998539 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJB05_RS19160 (3998562) 3998562..3999755 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280062 WP_001291435.1 NZ_CP124405:c3994444-3994226 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280062 WP_000344800.1 NZ_CP124405:c3994844-3994470 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References