Detailed information of TA system TA280061

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3825738..3827427
• Replicon: chromosome
• Accession: NZ_CP124405
• Organism: Escherichia coli strain AVS0935

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJB05_RS18340
• Protein ID: WP_000365807.1
• Coordinates: 3826507..3827427 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJB05_RS18335
• Protein ID: WP_001295795.1
• Coordinates: 3825738..3826520 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJB05_RS18330 (3822356)	3822356..3825454	-	3099	WP_000673070.1	type I restriction endonuclease	-
QJB05_RS18335 (3825738)	3825738..3826520	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJB05_RS18340 (3826507)	3826507..3827427	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJB05_RS18345 (3827592)	3827592..3828368	-	777	WP_000171155.1	site-specific integrase	-
QJB05_RS18350 (3828576)	3828576..3828911	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJB05_RS18355 (3829138)	3829138..3829296	-	159	Protein_3580	integrase	-
QJB05_RS18360 (3829345)	3829345..3829530	+	186	WP_000146240.1	hypothetical protein	-
QJB05_RS18365 (3829745)	3829745..3830359	+	615	WP_001019923.1	YagU family protein	-
QJB05_RS18370 (3830430)	3830430..3830596	+	167	Protein_3583	tail fiber assembly protein	-
QJB05_RS18375 (3830608)	3830608..3830937	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJB05_RS18380 (3831244)	3831244..3831954	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	3819488..3858089	38601

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280061 WP_000365807.1 NZ_CP124405:3826507-3827427 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280061 WP_001295795.1 NZ_CP124405:3825738-3826520 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0