Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3364422..3365257 | Replicon | chromosome |
| Accession | NZ_CP124405 | ||
| Organism | Escherichia coli strain AVS0935 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0J2AEA6 |
| Locus tag | QJB05_RS16100 | Protein ID | WP_000854759.1 |
| Coordinates | 3364880..3365257 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | QJB05_RS16095 | Protein ID | WP_001295723.1 |
| Coordinates | 3364422..3364790 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QJB05_RS16070 (3361537) | 3361537..3361732 | + | 196 | Protein_3134 | DUF905 family protein | - |
| QJB05_RS16075 (3361850) | 3361850..3362668 | + | 819 | WP_001234738.1 | DUF932 domain-containing protein | - |
| QJB05_RS16080 (3363010) | 3363010..3363483 | + | 474 | WP_001350782.1 | antirestriction protein | - |
| QJB05_RS16085 (3363499) | 3363499..3363975 | + | 477 | WP_001186775.1 | RadC family protein | - |
| QJB05_RS16090 (3364038) | 3364038..3364259 | + | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| QJB05_RS16095 (3364422) | 3364422..3364790 | + | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| QJB05_RS16100 (3364880) | 3364880..3365257 | + | 378 | WP_000854759.1 | TA system toxin CbtA family protein | Toxin |
| QJB05_RS16105 (3365254) | 3365254..3365742 | + | 489 | WP_000761690.1 | DUF5983 family protein | - |
| QJB05_RS16110 (3365759) | 3365759..3365935 | + | 177 | WP_000839286.1 | DUF957 domain-containing protein | - |
| QJB05_RS16115 (3366041) | 3366041..3366190 | + | 150 | Protein_3143 | hypothetical protein | - |
| QJB05_RS16120 (3366557) | 3366557..3366862 | + | 306 | Protein_3144 | helix-turn-helix domain-containing protein | - |
| QJB05_RS16125 (3367524) | 3367524..3369146 | + | 1623 | WP_001295726.1 | Alw26I/Eco31I/Esp3I family type II restriction adenine-specific DNA-methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14144.26 Da Isoelectric Point: 7.3249
>T280058 WP_000854759.1 NZ_CP124405:3364880-3365257 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT280058 WP_001295723.1 NZ_CP124405:3364422-3364790 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0J2AEA6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1NM52 |