Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2309252..2310052 Replicon chromosome
Accession NZ_CP124405
Organism Escherichia coli strain AVS0935

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJB05_RS11190 Protein ID WP_000342452.1
Coordinates 2309252..2309779 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJB05_RS11195 Protein ID WP_001277107.1
Coordinates 2309786..2310052 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB05_RS11165 (2304328) 2304328..2305095 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJB05_RS11170 (2305092) 2305092..2306369 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJB05_RS11175 (2306366) 2306366..2307292 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJB05_RS11180 (2307340) 2307340..2308449 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJB05_RS11185 (2308872) 2308872..2309255 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJB05_RS11190 (2309252) 2309252..2309779 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJB05_RS11195 (2309786) 2309786..2310052 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJB05_RS11200 (2310201) 2310201..2311304 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJB05_RS11205 (2311575) 2311575..2312429 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJB05_RS11210 (2312674) 2312674..2313732 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJB05_RS11215 (2313725) 2313725..2314393 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T280054 WP_000342452.1 NZ_CP124405:c2309779-2309252 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT280054 WP_001277107.1 NZ_CP124405:c2310052-2309786 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References