Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2384908..2385708 Replicon chromosome
Accession NZ_CP124400
Organism Escherichia coli strain AVS0528

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP80_RS11600 Protein ID WP_000342452.1
Coordinates 2384908..2385435 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP80_RS11605 Protein ID WP_001277107.1
Coordinates 2385442..2385708 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP80_RS11575 (2379984) 2379984..2380751 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJP80_RS11580 (2380748) 2380748..2382025 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP80_RS11585 (2382022) 2382022..2382948 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP80_RS11590 (2382996) 2382996..2384105 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP80_RS11595 (2384528) 2384528..2384911 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP80_RS11600 (2384908) 2384908..2385435 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP80_RS11605 (2385442) 2385442..2385708 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP80_RS11610 (2385857) 2385857..2386960 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP80_RS11615 (2387231) 2387231..2388085 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP80_RS11620 (2388330) 2388330..2389388 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJP80_RS11625 (2389381) 2389381..2390049 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T280024 WP_000342452.1 NZ_CP124400:c2385435-2384908 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT280024 WP_001277107.1 NZ_CP124400:c2385708-2385442 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References