Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4119788..4120406 Replicon chromosome
Accession NZ_CP124387
Organism Escherichia coli strain AVS0972

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJB01_RS19840 Protein ID WP_001291435.1
Coordinates 4119788..4120006 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJB01_RS19845 Protein ID WP_000344800.1
Coordinates 4120032..4120406 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB01_RS19805 (4115075) 4115075..4115647 + 573 WP_000779831.1 YbaY family lipoprotein -
QJB01_RS19810 (4115678) 4115678..4115989 - 312 WP_000409908.1 MGMT family protein -
QJB01_RS19820 (4116368) 4116368..4116721 + 354 WP_000878135.1 DUF1428 family protein -
QJB01_RS19825 (4116763) 4116763..4118313 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJB01_RS19830 (4118477) 4118477..4118947 - 471 WP_000136192.1 YlaC family protein -
QJB01_RS19835 (4119063) 4119063..4119614 - 552 WP_000102539.1 maltose O-acetyltransferase -
QJB01_RS19840 (4119788) 4119788..4120006 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QJB01_RS19845 (4120032) 4120032..4120406 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJB01_RS19850 (4120952) 4120952..4124101 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJB01_RS19855 (4124124) 4124124..4125317 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280000 WP_001291435.1 NZ_CP124387:c4120006-4119788 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280000 WP_000344800.1 NZ_CP124387:c4120406-4120032 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References