Detailed information of TA system TA279999

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3933858..3935547
• Replicon: chromosome
• Accession: NZ_CP124387
• Organism: Escherichia coli strain AVS0972

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJB01_RS18965
• Protein ID: WP_000365807.1
• Coordinates: 3934627..3935547 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJB01_RS18960
• Protein ID: WP_001295795.1
• Coordinates: 3933858..3934640 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJB01_RS18955 (3930476)	3930476..3933574	-	3099	WP_000673070.1	type I restriction endonuclease	-
QJB01_RS18960 (3933858)	3933858..3934640	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJB01_RS18965 (3934627)	3934627..3935547	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJB01_RS18970 (3935712)	3935712..3936488	-	777	WP_000171155.1	site-specific integrase	-
QJB01_RS18975 (3936696)	3936696..3937031	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJB01_RS18980 (3937258)	3937258..3937416	-	159	Protein_3710	integrase	-
QJB01_RS18985 (3937465)	3937465..3937650	+	186	WP_000146240.1	hypothetical protein	-
QJB01_RS18990 (3937865)	3937865..3938479	+	615	WP_001019923.1	YagU family protein	-
QJB01_RS18995 (3938550)	3938550..3938716	+	167	Protein_3713	tail fiber assembly protein	-
QJB01_RS19000 (3938728)	3938728..3939057	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJB01_RS19005 (3939364)	3939364..3940074	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	3927608..3976539	48931

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T279999 WP_000365807.1 NZ_CP124387:3934627-3935547 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT279999 WP_001295795.1 NZ_CP124387:3933858-3934640 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0