Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3275487..3275984 Replicon chromosome
Accession NZ_CP124387
Organism Escherichia coli strain AVS0972

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QJB01_RS15730 Protein ID WP_001173343.1
Coordinates 3275811..3275984 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag QJB01_RS15725 Protein ID WP_001312331.1
Coordinates 3275487..3275783 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB01_RS15715 (3270844) 3270844..3274773 + 3930 WP_001080129.1 autotransporter outer membrane beta-barrel domain-containing protein -
QJB01_RS15720 (3274987) 3274987..3275259 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
QJB01_RS15725 (3275487) 3275487..3275783 + 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QJB01_RS15730 (3275811) 3275811..3275984 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QJB01_RS15735 (3276103) 3276103..3277620 - 1518 WP_000003806.1 lysine--tRNA ligase -
QJB01_RS15740 (3277857) 3277857..3279314 - 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3259896..3284837 24941


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T279994 WP_001173343.1 NZ_CP124387:3275811-3275984 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT279994 WP_001312331.1 NZ_CP124387:3275487-3275783 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References