Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2392706..2393506 Replicon chromosome
Accession NZ_CP124387
Organism Escherichia coli strain AVS0972

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJB01_RS11640 Protein ID WP_000342452.1
Coordinates 2392706..2393233 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJB01_RS11645 Protein ID WP_001277107.1
Coordinates 2393240..2393506 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB01_RS11615 (2387782) 2387782..2388549 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJB01_RS11620 (2388546) 2388546..2389823 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJB01_RS11625 (2389820) 2389820..2390746 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJB01_RS11630 (2390794) 2390794..2391903 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJB01_RS11635 (2392326) 2392326..2392709 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJB01_RS11640 (2392706) 2392706..2393233 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJB01_RS11645 (2393240) 2393240..2393506 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJB01_RS11650 (2393655) 2393655..2394758 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJB01_RS11655 (2395029) 2395029..2395883 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJB01_RS11660 (2396128) 2396128..2397186 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJB01_RS11665 (2397179) 2397179..2397847 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T279991 WP_000342452.1 NZ_CP124387:c2393233-2392706 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT279991 WP_001277107.1 NZ_CP124387:c2393506-2393240 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References