Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1159516..1160136 Replicon chromosome
Accession NC_018079
Organism Enterobacter cloacae subsp. dissolvens SDM

Toxin (Protein)


Gene name Hha Uniprot ID A0A5E1A1U8
Locus tag A3UG_RS05380 Protein ID WP_013095889.1
Coordinates 1159516..1159734 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag A3UG_RS05385 Protein ID WP_008499288.1
Coordinates 1159762..1160136 (-) Length 125 a.a.

Genomic Context

A3UG_RS05350A3UG_RS05355A3UG_RS05365A3UG_RS05360A3UG_RS05370A3UG_RS05375A3UG_RS05380A3UG_RS05385A3UG_RS05390A3UG_RS05395
Location: 1155528..1155788 (261 bp)
Type: Others
Protein ID: WP_010428154.1
Location: 1155791..1155931 (141 bp)
Type: Others
Protein ID: WP_003859006.1
Location: 1156740..1158200 (1461 bp)
Type: Others
Protein ID: WP_014830899.1
Location: 1155928..1156638 (711 bp)
Type: Others
Protein ID: WP_014830898.1
Location: 1158172..1158639 (468 bp)
Type: Others
Protein ID: WP_014830900.1
Location: 1158755..1159306 (552 bp)
Type: Others
Protein ID: WP_014830901.1
Location: 1159516..1159734 (219 bp)
Type: Toxin
Protein ID: WP_013095889.1
Location: 1159762..1160136 (375 bp)
Type: Antitoxin
Protein ID: WP_008499288.1
Location: 1160649..1163795 (3147 bp)
Type: Others
Protein ID: WP_014830902.1
Location: 1163818..1165011 (1194 bp)
Type: Others
Protein ID: WP_014830903.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A3UG_RS053501155528..1155788+261WP_010428154.1type B 50S ribosomal protein L31-
A3UG_RS053551155791..1155931+141WP_003859006.1type B 50S ribosomal protein L36-
A3UG_RS053601155928..1156638-711WP_014830898.1GNAT family N-acetyltransferase-
A3UG_RS053651156740..1158200+1461WP_014830899.1PLP-dependent aminotransferase family protein-
A3UG_RS053701158172..1158639-468WP_014830900.1membrane protein-
A3UG_RS053751158755..1159306-552WP_014830901.1maltose O-acetyltransferase-
A3UG_RS053801159516..1159734-219WP_013095889.1hemolysin expression modulator HhaToxin
A3UG_RS053851159762..1160136-375WP_008499288.1Hha toxicity modulator TomBAntitoxin
A3UG_RS053901160649..1163795-3147WP_014830902.1multidrug efflux RND transporter permease subunit-
A3UG_RS053951163818..1165011-1194WP_014830903.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8625.98 Da        Isoelectric Point: 8.9008

>T27999 WP_013095889.1 NC_018079:c1159734-1159516 [Enterobacter cloacae subsp. dissolvens SDM]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELTVFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 219 bp

>T27999 NC_018079:c1159734-1159516 [Enterobacter cloacae subsp. dissolvens SDM]
ATGTCTGATAAACCACTCACAAAAACCGATTATTTGATGCGCTTACGACGCTGTCAATCAATTGACACGCTCGAACGTGT
TATTGAAAAAAATAAATACGAGCTTTCTGATAATGAACTGACTGTATTTTATTCTGCGGCGGACCACCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAAATCCCCCCTTCCGTGTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT27999 WP_008499288.1 NC_018079:c1160136-1159762 [Enterobacter cloacae subsp. dissolvens SDM]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT27999 NC_018079:c1160136-1159762 [Enterobacter cloacae subsp. dissolvens SDM]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAATCATGGCTGGGTGAACGATCCAACGTCTGCCATCAATTTACAATTGAATGAGTTGATAGAGC
ATATCGCGACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGACGAATACCTG
GATGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCTGGAAACCGGCT
ATTCCGTTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTTAGCCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A5E1A1U8

Antitoxin

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Source
ID
Structure
AlphaFold DBV3PBI9

References