Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1712728..1713382 Replicon chromosome
Accession NZ_CP124387
Organism Escherichia coli strain AVS0972

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJB01_RS08190 Protein ID WP_000244765.1
Coordinates 1712728..1713135 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJB01_RS08195 Protein ID WP_000354050.1
Coordinates 1713116..1713382 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB01_RS08170 (1708685) 1708685..1710418 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
QJB01_RS08175 (1710424) 1710424..1711134 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJB01_RS08180 (1711159) 1711159..1712055 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJB01_RS08185 (1712167) 1712167..1712688 + 522 WP_001055874.1 flavodoxin FldB -
QJB01_RS08190 (1712728) 1712728..1713135 - 408 WP_000244765.1 protein YgfX Toxin
QJB01_RS08195 (1713116) 1713116..1713382 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJB01_RS08200 (1713625) 1713625..1714605 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
QJB01_RS08205 (1714682) 1714682..1715341 - 660 WP_000250275.1 hemolysin III family protein -
QJB01_RS08210 (1715505) 1715505..1715816 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJB01_RS08215 (1715861) 1715861..1717294 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T279987 WP_000244765.1 NZ_CP124387:c1713135-1712728 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT279987 WP_000354050.1 NZ_CP124387:c1713382-1713116 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References