Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 187399..188003 Replicon chromosome
Accession NC_018079
Organism Enterobacter cloacae subsp. dissolvens SDM

Toxin (Protein)


Gene name hicA Uniprot ID A0A427KHJ9
Locus tag A3UG_RS23405 Protein ID WP_014830187.1
Coordinates 187399..187584 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A427KHG9
Locus tag A3UG_RS00950 Protein ID WP_014830188.1
Coordinates 187599..188003 (+) Length 135 a.a.

Genomic Context

A3UG_RS00935A3UG_RS00945A3UG_RS23405A3UG_RS00950A3UG_RS00965A3UG_RS00940A3UG_RS00955A3UG_RS00960
Location: 183830..185368 (1539 bp)
Type: Others
Protein ID: WP_014830184.1
Location: 186448..187188 (741 bp)
Type: Others
Protein ID: WP_014830186.1
Location: 187399..187584 (186 bp)
Type: Toxin
Protein ID: WP_014830187.1
Location: 187599..188003 (405 bp)
Type: Antitoxin
Protein ID: WP_014830188.1
Location: 191648..192466 (819 bp)
Type: Others
Protein ID: WP_014830191.1
Location: 185365..186330 (966 bp)
Type: Others
Protein ID: WP_014830185.1
Location: 188057..190012 (1956 bp)
Type: Others
Protein ID: WP_014830189.1
Location: 190023..191423 (1401 bp)
Type: Others
Protein ID: WP_014830190.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A3UG_RS00935183830..185368+1539WP_014830184.1aldehyde dehydrogenase-
A3UG_RS00940185365..186330-966WP_014830185.1LysR family transcriptional regulator-
A3UG_RS00945186448..187188+741WP_014830186.1MipA/OmpV family protein-
A3UG_RS23405187399..187584+186WP_014830187.1type II toxin-antitoxin system HicA family toxinToxin
A3UG_RS00950187599..188003+405WP_014830188.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
A3UG_RS00955188057..190012-1956WP_014830189.1glycoside hydrolase family 127 protein-
A3UG_RS00960190023..191423-1401WP_014830190.1MFS transporter-
A3UG_RS00965191648..192466+819WP_014830191.1helix-turn-helix domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6844.06 Da        Isoelectric Point: 11.7507

>T27998 WP_014830187.1 NC_018079:187399-187584 [Enterobacter cloacae subsp. dissolvens SDM]
VISADVITVLVRHGWKCVRTKGSHHQFRHPVHAGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T27998 NC_018079:187399-187584 [Enterobacter cloacae subsp. dissolvens SDM]
GTGATAAGTGCGGATGTCATTACTGTTCTGGTCAGGCATGGCTGGAAATGTGTAAGAACGAAAGGAAGCCATCATCAGTT
TCGCCACCCAGTACATGCGGGGTTGGTGACCGTTCCACATCCCAAAAAGGACATAAAACCCGGCACCCTCGCGCAAATCT
GGCGGCAGGCGGGAATCAAACACTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14902.74 Da        Isoelectric Point: 4.3129

>AT27998 WP_014830188.1 NC_018079:187599-188003 [Enterobacter cloacae subsp. dissolvens SDM]
MFYPAYIHSDPDGSASGFFPDVPGCFFAGNSLDDAFQDAREALTAHFEALFEMDEELPLPGNVEAHLEATPGDFIGGQWL
LVDINMKQFDGKAERINITLPRRLLVKIDSFVSEHPQFSNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT27998 NC_018079:187599-188003 [Enterobacter cloacae subsp. dissolvens SDM]
ATGTTTTATCCGGCTTACATTCATTCTGATCCCGACGGTAGCGCCAGCGGTTTTTTTCCTGACGTTCCTGGTTGTTTTTT
TGCCGGCAATTCTCTGGATGATGCTTTTCAGGATGCACGTGAAGCACTGACAGCTCACTTCGAAGCGCTATTTGAAATGG
ATGAAGAGTTACCTCTCCCTGGCAATGTTGAAGCACATCTTGAAGCCACACCGGGTGATTTTATCGGCGGACAATGGTTG
CTTGTAGATATCAATATGAAGCAATTCGACGGTAAGGCCGAACGTATCAATATCACCCTGCCTCGTCGATTGCTGGTGAA
AATTGATTCTTTTGTGAGTGAACATCCGCAGTTTAGTAACCGAAGCGCTTTTCTGGCTGAGGCAGCGCGTCGCGTGCTGC
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A427KHJ9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A427KHG9

References