Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 187399..188003 Replicon chromosome
Accession NC_018079
Organism Enterobacter cloacae subsp. dissolvens SDM

Toxin (Protein)


Gene name hicA Uniprot ID A0A427KHJ9
Locus tag A3UG_RS23405 Protein ID WP_014830187.1
Coordinates 187399..187584 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A427KHG9
Locus tag A3UG_RS00950 Protein ID WP_014830188.1
Coordinates 187599..188003 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3UG_RS00935 183830..185368 + 1539 WP_014830184.1 aldehyde dehydrogenase -
A3UG_RS00940 185365..186330 - 966 WP_014830185.1 LysR family transcriptional regulator -
A3UG_RS00945 186448..187188 + 741 WP_014830186.1 MipA/OmpV family protein -
A3UG_RS23405 187399..187584 + 186 WP_014830187.1 type II toxin-antitoxin system HicA family toxin Toxin
A3UG_RS00950 187599..188003 + 405 WP_014830188.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A3UG_RS00955 188057..190012 - 1956 WP_014830189.1 glycoside hydrolase family 127 protein -
A3UG_RS00960 190023..191423 - 1401 WP_014830190.1 MFS transporter -
A3UG_RS00965 191648..192466 + 819 WP_014830191.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6844.06 Da        Isoelectric Point: 11.7507

>T27998 WP_014830187.1 NC_018079:187399-187584 [Enterobacter cloacae subsp. dissolvens SDM]
VISADVITVLVRHGWKCVRTKGSHHQFRHPVHAGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T27998 NC_018079:187399-187584 [Enterobacter cloacae subsp. dissolvens SDM]
GTGATAAGTGCGGATGTCATTACTGTTCTGGTCAGGCATGGCTGGAAATGTGTAAGAACGAAAGGAAGCCATCATCAGTT
TCGCCACCCAGTACATGCGGGGTTGGTGACCGTTCCACATCCCAAAAAGGACATAAAACCCGGCACCCTCGCGCAAATCT
GGCGGCAGGCGGGAATCAAACACTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14902.74 Da        Isoelectric Point: 4.3129

>AT27998 WP_014830188.1 NC_018079:187599-188003 [Enterobacter cloacae subsp. dissolvens SDM]
MFYPAYIHSDPDGSASGFFPDVPGCFFAGNSLDDAFQDAREALTAHFEALFEMDEELPLPGNVEAHLEATPGDFIGGQWL
LVDINMKQFDGKAERINITLPRRLLVKIDSFVSEHPQFSNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT27998 NC_018079:187599-188003 [Enterobacter cloacae subsp. dissolvens SDM]
ATGTTTTATCCGGCTTACATTCATTCTGATCCCGACGGTAGCGCCAGCGGTTTTTTTCCTGACGTTCCTGGTTGTTTTTT
TGCCGGCAATTCTCTGGATGATGCTTTTCAGGATGCACGTGAAGCACTGACAGCTCACTTCGAAGCGCTATTTGAAATGG
ATGAAGAGTTACCTCTCCCTGGCAATGTTGAAGCACATCTTGAAGCCACACCGGGTGATTTTATCGGCGGACAATGGTTG
CTTGTAGATATCAATATGAAGCAATTCGACGGTAAGGCCGAACGTATCAATATCACCCTGCCTCGTCGATTGCTGGTGAA
AATTGATTCTTTTGTGAGTGAACATCCGCAGTTTAGTAACCGAAGCGCTTTTCTGGCTGAGGCAGCGCGTCGCGTGCTGC
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A427KHJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A427KHG9

References