Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3588313..3588908 Replicon chromosome
Accession NZ_CP124385
Organism Escherichia coli strain AVS0153

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QJP67_RS17640 Protein ID WP_000239579.1
Coordinates 3588558..3588908 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QJP67_RS17635 Protein ID WP_001223208.1
Coordinates 3588313..3588564 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP67_RS17625 (3583978) 3583978..3587757 + 3780 WP_000060945.1 autotransporter assembly complex protein TamB -
QJP67_RS17630 (3587760) 3587760..3588101 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QJP67_RS17635 (3588313) 3588313..3588564 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QJP67_RS17640 (3588558) 3588558..3588908 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QJP67_RS17645 (3588988) 3588988..3589518 - 531 WP_000055075.1 inorganic diphosphatase -
QJP67_RS17650 (3589828) 3589828..3590784 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QJP67_RS17655 (3590924) 3590924..3592426 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
QJP67_RS17660 (3592440) 3592440..3593462 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T279963 WP_000239579.1 NZ_CP124385:3588558-3588908 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT279963 WP_001223208.1 NZ_CP124385:3588313-3588564 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References