Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2553317..2554117 Replicon chromosome
Accession NZ_CP124385
Organism Escherichia coli strain AVS0153

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP67_RS12785 Protein ID WP_000342452.1
Coordinates 2553317..2553844 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP67_RS12790 Protein ID WP_001277107.1
Coordinates 2553851..2554117 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP67_RS12760 (2548393) 2548393..2549160 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJP67_RS12765 (2549157) 2549157..2550434 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP67_RS12770 (2550431) 2550431..2551357 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP67_RS12775 (2551405) 2551405..2552514 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP67_RS12780 (2552937) 2552937..2553320 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP67_RS12785 (2553317) 2553317..2553844 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP67_RS12790 (2553851) 2553851..2554117 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP67_RS12795 (2554266) 2554266..2555369 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP67_RS12800 (2555640) 2555640..2556494 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP67_RS12805 (2556739) 2556739..2557797 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJP67_RS12810 (2557790) 2557790..2558458 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T279959 WP_000342452.1 NZ_CP124385:c2553844-2553317 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT279959 WP_001277107.1 NZ_CP124385:c2554117-2553851 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References