Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3767747..3768276 Replicon chromosome
Accession NC_018078
Organism Mycobacterium tuberculosis KZN 605

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag TBXG_RS17740 Protein ID WP_003417760.1
Coordinates 3768019..3768276 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag TBXG_RS17735 Protein ID WP_003417757.1
Coordinates 3767747..3768022 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBXG_RS22585 3764545..3765982 - 1438 Protein_3463 FAD-binding oxidoreductase -
TBXG_RS17720 3766085..3766474 + 390 WP_003417745.1 DUF732 domain-containing protein -
TBXG_RS17725 3766488..3766781 - 294 WP_003417749.1 DUF3017 domain-containing protein -
TBXG_RS17730 3766778..3767623 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
TBXG_RS17735 3767747..3768022 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
TBXG_RS17740 3768019..3768276 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
TBXG_RS17745 3768318..3769508 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
TBXG_RS17750 3769625..3769993 + 369 WP_003417765.1 FHA domain-containing protein -
TBXG_RS17755 3769990..3770541 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
TBXG_RS17760 3770548..3771129 - 582 WP_003417769.1 ATP/GTP-binding protein -
TBXG_RS17765 3771110..3771478 - 369 WP_003417772.1 DUF742 domain-containing protein -
TBXG_RS17770 3771456..3771848 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T27995 WP_003417760.1 NC_018078:3768019-3768276 [Mycobacterium tuberculosis KZN 605]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T27995 NC_018078:3768019-3768276 [Mycobacterium tuberculosis KZN 605]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT27995 WP_003417757.1 NC_018078:3767747-3768022 [Mycobacterium tuberculosis KZN 605]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT27995 NC_018078:3767747-3768022 [Mycobacterium tuberculosis KZN 605]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References