Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1773..2320 Replicon plasmid pAVS0578-C
Accession NZ_CP124377
Organism Escherichia coli strain AVS0578

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag QJP97_RS26540 Protein ID WP_001384452.1
Coordinates 2042..2320 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag QJP97_RS26535 Protein ID WP_000079928.1
Coordinates 1773..2042 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP97_RS26530 (1) 1..858 + 858 WP_042018306.1 incFII family plasmid replication initiator RepA -
QJP97_RS26535 (1773) 1773..2042 + 270 WP_000079928.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QJP97_RS26540 (2042) 2042..2320 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
QJP97_RS26545 (2366) 2366..3214 + 849 WP_016235419.1 3'-5' exonuclease -
QJP97_RS26550 (3331) 3331..3813 + 483 WP_001311056.1 hypothetical protein -
QJP97_RS26555 (4173) 4173..5360 - 1188 Protein_5 IS91 family transposase -
QJP97_RS26560 (5360) 5360..5725 - 366 WP_016235422.1 hypothetical protein -
QJP97_RS26565 (6253) 6253..6762 + 510 WP_000114984.1 peptide deformylase -
QJP97_RS26570 (6777) 6777..6878 + 102 Protein_8 methionyl-tRNA formyltransferase -
QJP97_RS26575 (7074) 7074..7265 + 192 WP_000175572.1 DUF2164 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..72619 72619


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T279947 WP_001384452.1 NZ_CP124377:2042-2320 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10175.50 Da        Isoelectric Point: 7.3210

>AT279947 WP_000079928.1 NZ_CP124377:1773-2042 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References