Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 63137..63738 Replicon plasmid pAVS0578-B
Accession NZ_CP124376
Organism Escherichia coli strain AVS0578

Toxin (Protein)


Gene name doc Uniprot ID F4TND7
Locus tag QJP97_RS26275 Protein ID WP_001216030.1
Coordinates 63137..63517 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag QJP97_RS26280 Protein ID WP_001190712.1
Coordinates 63517..63738 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP97_RS26250 (QJP97_26245) 58577..60061 - 1485 WP_000124150.1 terminase -
QJP97_RS26255 (QJP97_26250) 60061..61254 - 1194 WP_282526075.1 terminase -
QJP97_RS26260 (QJP97_26255) 61341..61793 - 453 WP_001312282.1 late promoter-activating protein (Gp10) -
QJP97_RS26265 (QJP97_26260) 61882..62925 - 1044 WP_282526076.1 DUF968 domain-containing protein -
QJP97_RS26270 (QJP97_26265) 62953..63132 - 180 WP_000113018.1 hypothetical protein -
QJP97_RS26275 (QJP97_26270) 63137..63517 - 381 WP_001216030.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
QJP97_RS26280 (QJP97_26275) 63517..63738 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QJP97_RS26285 (QJP97_26280) 63811..64200 - 390 WP_000506726.1 S24 family peptidase -
QJP97_RS26290 (QJP97_26285) 64324..64575 - 252 WP_046644566.1 DNA polymerase III subunit theta -
QJP97_RS26295 (QJP97_26290) 65025..65162 + 138 WP_000123562.1 hypothetical protein -
QJP97_RS26300 (QJP97_26295) 65237..65599 - 363 WP_001261544.1 hypothetical protein -
QJP97_RS26305 (QJP97_26300) 65596..66489 - 894 WP_282526081.1 hypothetical protein -
QJP97_RS26310 (QJP97_26305) 66463..66588 - 126 Protein_68 hypothetical protein -
QJP97_RS26315 (QJP97_26310) 66599..66862 - 264 WP_000224227.1 hypothetical protein -
QJP97_RS26320 (QJP97_26315) 67083..67232 - 150 Protein_70 hypothetical protein -
QJP97_RS26325 (QJP97_26320) 67229..67438 - 210 WP_023156633.1 hypothetical protein -
QJP97_RS26330 (QJP97_26325) 67440..67628 - 189 WP_000797279.1 hypothetical protein -
QJP97_RS26335 (QJP97_26330) 67977..68423 - 447 WP_023156632.1 ead/Ea22-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..94894 94894


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13601.29 Da        Isoelectric Point: 5.1408

>T279946 WP_001216030.1 NZ_CP124376:c63517-63137 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEDITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT279946 WP_001190712.1 NZ_CP124376:c63738-63517 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M1W8Q3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References