Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4555145..4555945 Replicon chromosome
Accession NZ_CP124374
Organism Escherichia coli strain AVS0578

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP97_RS22535 Protein ID WP_000342452.1
Coordinates 4555145..4555672 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP97_RS22540 Protein ID WP_001277107.1
Coordinates 4555679..4555945 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP97_RS22510 (4550221) 4550221..4550988 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJP97_RS22515 (4550985) 4550985..4552262 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP97_RS22520 (4552259) 4552259..4553185 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP97_RS22525 (4553233) 4553233..4554342 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP97_RS22530 (4554765) 4554765..4555148 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP97_RS22535 (4555145) 4555145..4555672 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP97_RS22540 (4555679) 4555679..4555945 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP97_RS22545 (4556094) 4556094..4557197 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP97_RS22550 (4557468) 4557468..4558322 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP97_RS22555 (4558567) 4558567..4559625 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJP97_RS22560 (4559618) 4559618..4560286 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T279937 WP_000342452.1 NZ_CP124374:c4555672-4555145 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT279937 WP_001277107.1 NZ_CP124374:c4555945-4555679 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References