Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3901932..3902586 Replicon chromosome
Accession NZ_CP124374
Organism Escherichia coli strain AVS0578

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJP97_RS19230 Protein ID WP_000244765.1
Coordinates 3901932..3902339 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJP97_RS19235 Protein ID WP_000354050.1
Coordinates 3902320..3902586 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP97_RS19210 (3897889) 3897889..3899622 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
QJP97_RS19215 (3899628) 3899628..3900338 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJP97_RS19220 (3900363) 3900363..3901259 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJP97_RS19225 (3901371) 3901371..3901892 + 522 WP_001055874.1 flavodoxin FldB -
QJP97_RS19230 (3901932) 3901932..3902339 - 408 WP_000244765.1 protein YgfX Toxin
QJP97_RS19235 (3902320) 3902320..3902586 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJP97_RS19240 (3902829) 3902829..3903809 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
QJP97_RS19245 (3903886) 3903886..3904545 - 660 WP_000250275.1 hemolysin III family protein -
QJP97_RS19250 (3904709) 3904709..3905020 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJP97_RS19255 (3905065) 3905065..3906498 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T279933 WP_000244765.1 NZ_CP124374:c3902339-3901932 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT279933 WP_000354050.1 NZ_CP124374:c3902586-3902320 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References