Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1208761..1209379 Replicon chromosome
Accession NZ_CP124374
Organism Escherichia coli strain AVS0578

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP97_RS05820 Protein ID WP_001291435.1
Coordinates 1208761..1208979 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP97_RS05825 Protein ID WP_000344800.1
Coordinates 1209005..1209379 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP97_RS05785 (1204048) 1204048..1204620 + 573 WP_000779831.1 YbaY family lipoprotein -
QJP97_RS05790 (1204651) 1204651..1204962 - 312 WP_000409908.1 MGMT family protein -
QJP97_RS05800 (1205341) 1205341..1205694 + 354 WP_000878135.1 DUF1428 family protein -
QJP97_RS05805 (1205736) 1205736..1207286 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP97_RS05810 (1207450) 1207450..1207920 - 471 WP_000136192.1 YlaC family protein -
QJP97_RS05815 (1208036) 1208036..1208587 - 552 WP_000102539.1 maltose O-acetyltransferase -
QJP97_RS05820 (1208761) 1208761..1208979 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP97_RS05825 (1209005) 1209005..1209379 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP97_RS05830 (1209925) 1209925..1213074 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP97_RS05835 (1213097) 1213097..1214290 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T279920 WP_001291435.1 NZ_CP124374:c1208979-1208761 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT279920 WP_000344800.1 NZ_CP124374:c1209379-1209005 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References