Detailed information of TA system TA279919

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1024383..1026072
• Replicon: chromosome
• Accession: NZ_CP124374
• Organism: Escherichia coli strain AVS0578

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP97_RS04960
• Protein ID: WP_000365807.1
• Coordinates: 1025152..1026072 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP97_RS04955
• Protein ID: WP_001295795.1
• Coordinates: 1024383..1025165 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP97_RS04950 (1021001)	1021001..1024099	-	3099	WP_000673070.1	type I restriction endonuclease	-
QJP97_RS04955 (1024383)	1024383..1025165	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP97_RS04960 (1025152)	1025152..1026072	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP97_RS04965 (1026237)	1026237..1027013	-	777	WP_000171155.1	site-specific integrase	-
QJP97_RS04970 (1027221)	1027221..1027556	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP97_RS04975 (1027783)	1027783..1027941	-	159	Protein_967	integrase	-
QJP97_RS04980 (1027990)	1027990..1028175	+	186	WP_000146240.1	hypothetical protein	-
QJP97_RS04985 (1028390)	1028390..1029004	+	615	WP_001019923.1	YagU family protein	-
QJP97_RS04990 (1029075)	1029075..1029241	+	167	Protein_970	tail fiber assembly protein	-
QJP97_RS04995 (1029253)	1029253..1029582	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP97_RS05000 (1029889)	1029889..1030599	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	1018133..1066288	48155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T279919 WP_000365807.1 NZ_CP124374:1025152-1026072 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT279919 WP_001295795.1 NZ_CP124374:1024383-1025165 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0