Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 518956..519791 Replicon chromosome
Accession NZ_CP124374
Organism Escherichia coli strain AVS0578

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag QJP97_RS02460 Protein ID WP_000854759.1
Coordinates 519414..519791 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag QJP97_RS02455 Protein ID WP_001295723.1
Coordinates 518956..519324 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP97_RS02430 (514958) 514958..515431 + 474 WP_001350782.1 antirestriction protein -
QJP97_RS02435 (515447) 515447..515923 + 477 WP_001186774.1 RadC family protein -
QJP97_RS02440 (515986) 515986..516240 + 255 WP_023281719.1 DUF987 domain-containing protein -
QJP97_RS02445 (516381) 516381..517922 + 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
QJP97_RS02450 (517937) 517937..518683 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
QJP97_RS02455 (518956) 518956..519324 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QJP97_RS02460 (519414) 519414..519791 + 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
QJP97_RS02465 (519788) 519788..520276 + 489 WP_000761690.1 DUF5983 family protein -
QJP97_RS02470 (520293) 520293..520469 + 177 WP_000839286.1 DUF957 domain-containing protein -
QJP97_RS02475 (520575) 520575..520724 + 150 Protein_476 hypothetical protein -
QJP97_RS02480 (521091) 521091..521267 + 177 Protein_477 helix-turn-helix domain-containing protein -
QJP97_RS02485 (522058) 522058..523680 + 1623 WP_001295726.1 Alw26I/Eco31I/Esp3I family type II restriction adenine-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T279916 WP_000854759.1 NZ_CP124374:519414-519791 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT279916 WP_001295723.1 NZ_CP124374:518956-519324 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References