Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 140119..140762 Replicon plasmid pAVS0151-A
Accession NZ_CP124373
Organism Escherichia coli strain AVS0151

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag QJP92_RS27080 Protein ID WP_001034044.1
Coordinates 140346..140762 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag QJP92_RS27075 Protein ID WP_001261286.1
Coordinates 140119..140349 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP92_RS27055 (136750) 136750..137505 - 756 WP_000852146.1 replication initiation protein RepE -
QJP92_RS27060 (138227) 138227..139033 - 807 WP_000016970.1 site-specific integrase -
QJP92_RS27065 (139034) 139034..139339 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB -
QJP92_RS27070 (139341) 139341..139559 - 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA -
QJP92_RS27075 (140119) 140119..140349 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QJP92_RS27080 (140346) 140346..140762 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
QJP92_RS27085 (140837) 140837..142402 + 1566 WP_001128474.1 AAA family ATPase -
QJP92_RS27090 (142387) 142387..143409 + 1023 WP_000361402.1 helicase UvrD -
QJP92_RS27095 (143663) 143663..144349 - 687 Protein_177 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aadA5 / qacE / sul1 / mph(A) / tet(A) senB / iutA / iutA / iucD 1..150420 150420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T279913 WP_001034044.1 NZ_CP124373:140346-140762 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT279913 WP_001261286.1 NZ_CP124373:140119-140349 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References