Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4378455..4379109 Replicon chromosome
Accession NZ_CP124372
Organism Escherichia coli strain AVS0151

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJP92_RS22050 Protein ID WP_000244765.1
Coordinates 4378702..4379109 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJP92_RS22045 Protein ID WP_000354050.1
Coordinates 4378455..4378721 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP92_RS22025 (4374543) 4374543..4375976 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
QJP92_RS22030 (4376021) 4376021..4376332 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJP92_RS22035 (4376496) 4376496..4377155 + 660 WP_000250275.1 hemolysin III family protein -
QJP92_RS22040 (4377232) 4377232..4378212 - 981 WP_000886084.1 tRNA-modifying protein YgfZ -
QJP92_RS22045 (4378455) 4378455..4378721 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJP92_RS22050 (4378702) 4378702..4379109 + 408 WP_000244765.1 protein YgfX Toxin
QJP92_RS22055 (4379149) 4379149..4379670 - 522 WP_205940167.1 flavodoxin FldB -
QJP92_RS22060 (4379782) 4379782..4380678 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJP92_RS22065 (4380703) 4380703..4381413 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJP92_RS22070 (4381419) 4381419..4383152 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T279903 WP_000244765.1 NZ_CP124372:4378702-4379109 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT279903 WP_000354050.1 NZ_CP124372:4378455-4378721 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References