Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3715106..3715906 Replicon chromosome
Accession NZ_CP124372
Organism Escherichia coli strain AVS0151

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP92_RS18670 Protein ID WP_000342452.1
Coordinates 3715379..3715906 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP92_RS18665 Protein ID WP_001277107.1
Coordinates 3715106..3715372 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP92_RS18645 (3710765) 3710765..3711433 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
QJP92_RS18650 (3711426) 3711426..3712484 + 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJP92_RS18655 (3712729) 3712729..3713583 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP92_RS18660 (3713854) 3713854..3714957 + 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP92_RS18665 (3715106) 3715106..3715372 + 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP92_RS18670 (3715379) 3715379..3715906 + 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP92_RS18675 (3715903) 3715903..3716286 - 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP92_RS18680 (3716709) 3716709..3717818 + 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP92_RS18685 (3717866) 3717866..3718792 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP92_RS18690 (3718789) 3718789..3720066 + 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP92_RS18695 (3720063) 3720063..3720830 + 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T279899 WP_000342452.1 NZ_CP124372:3715379-3715906 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT279899 WP_001277107.1 NZ_CP124372:3715106-3715372 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References