Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2606911..2607506 Replicon chromosome
Accession NZ_CP124372
Organism Escherichia coli strain AVS0151

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QJP92_RS13310 Protein ID WP_000239579.1
Coordinates 2606911..2607261 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QJP92_RS13315 Protein ID WP_001223208.1
Coordinates 2607255..2607506 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP92_RS13290 (2602357) 2602357..2603379 - 1023 WP_001296689.1 ABC transporter permease -
QJP92_RS13295 (2603393) 2603393..2604895 - 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
QJP92_RS13300 (2605035) 2605035..2605991 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QJP92_RS13305 (2606301) 2606301..2606831 + 531 WP_000055075.1 inorganic diphosphatase -
QJP92_RS13310 (2606911) 2606911..2607261 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QJP92_RS13315 (2607255) 2607255..2607506 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QJP92_RS13320 (2607718) 2607718..2608059 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QJP92_RS13325 (2608062) 2608062..2611841 - 3780 WP_000060945.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T279895 WP_000239579.1 NZ_CP124372:c2607261-2606911 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT279895 WP_001223208.1 NZ_CP124372:c2607506-2607255 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References