Detailed information of TA system TA279891

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2048105..2049794
• Replicon: chromosome
• Accession: NZ_CP124372
• Organism: Escherichia coli strain AVS0151

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP92_RS10585
• Protein ID: WP_000365807.1
• Coordinates: 2048105..2049025 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP92_RS10590
• Protein ID: WP_001295795.1
• Coordinates: 2049012..2049794 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP92_RS10545 (2043578)	2043578..2044288	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP92_RS10550 (2044595)	2044595..2044924	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP92_RS10555 (2044936)	2044936..2045102	-	167	Protein_2077	tail fiber assembly protein	-
QJP92_RS10560 (2045173)	2045173..2045787	-	615	WP_001019923.1	YagU family protein	-
QJP92_RS10565 (2046002)	2046002..2046187	-	186	WP_000146240.1	hypothetical protein	-
QJP92_RS10570 (2046236)	2046236..2046394	+	159	Protein_2080	integrase	-
QJP92_RS10575 (2046621)	2046621..2046956	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP92_RS10580 (2047164)	2047164..2047940	+	777	WP_000171155.1	site-specific integrase	-
QJP92_RS10585 (2048105)	2048105..2049025	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP92_RS10590 (2049012)	2049012..2049794	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP92_RS10595 (2050078)	2050078..2053176	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	2007891..2056857	48966

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T279891 WP_000365807.1 NZ_CP124372:c2049025-2048105 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT279891 WP_001295795.1 NZ_CP124372:c2049794-2049012 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0