Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1864800..1865418 Replicon chromosome
Accession NZ_CP124372
Organism Escherichia coli strain AVS0151

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP92_RS09725 Protein ID WP_001291435.1
Coordinates 1865200..1865418 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP92_RS09720 Protein ID WP_000344800.1
Coordinates 1864800..1865174 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP92_RS09710 (1859889) 1859889..1861082 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QJP92_RS09715 (1861105) 1861105..1864254 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP92_RS09720 (1864800) 1864800..1865174 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP92_RS09725 (1865200) 1865200..1865418 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP92_RS09730 (1865592) 1865592..1866143 + 552 WP_000102539.1 maltose O-acetyltransferase -
QJP92_RS09735 (1866259) 1866259..1866729 + 471 WP_000136192.1 YlaC family protein -
QJP92_RS09740 (1866893) 1866893..1868443 + 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP92_RS09745 (1868485) 1868485..1868838 - 354 WP_000878135.1 DUF1428 family protein -
QJP92_RS09755 (1869217) 1869217..1869528 + 312 WP_000409908.1 MGMT family protein -
QJP92_RS09760 (1869559) 1869559..1870131 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T279890 WP_001291435.1 NZ_CP124372:1865200-1865418 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT279890 WP_000344800.1 NZ_CP124372:1864800-1865174 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References