279881

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 79866..80509 Replicon plasmid pAVS0465-A
Accession NZ_CP124368
Organism Escherichia coli strain AVS0465

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag QJP75_RS25890 Protein ID WP_001034044.1
Coordinates 80093..80509 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag QJP75_RS25885 Protein ID WP_001261286.1
Coordinates 79866..80096 (+) Length 77 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP75_RS25870 (75003) 75003..75233 + 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin -
QJP75_RS25875 (75230) 75230..75646 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -
QJP75_RS25880 (75691) 75691..79485 - 3795 WP_001144732.1 hypothetical protein -
QJP75_RS25885 (79866) 79866..80096 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QJP75_RS25890 (80093) 80093..80509 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
QJP75_RS25895 (80584) 80584..82149 + 1566 WP_001128474.1 AAA family ATPase -
QJP75_RS25900 (82134) 82134..83156 + 1023 WP_000361402.1 helicase UvrD -
QJP75_RS25910 (84141) 84141..84409 - 269 Protein_99 type II toxin-antitoxin system RelE/ParE family toxin -
QJP75_RS25915 (84396) 84396..84664 - 269 Protein_100 type II toxin-antitoxin system ParD family antitoxin -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qacE / sul1 / mph(A) / dfrA17 / blaCTX-M-15 / blaOXA-1 / aac(6')-Ib-cr - 1..103076 103076
- flank IS/Tn - - 83410..83913 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-129)

Antitoxin

(7-52)


Sequences


Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T279881 WP_001034044.1 NZ_CP124368:80093-80509 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp


Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT279881 WP_001261286.1 NZ_CP124368:79866-80096 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829CHW1


Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References