279880

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 75003..75646 Replicon plasmid pAVS0465-A
Accession NZ_CP124368
Organism Escherichia coli strain AVS0465

Toxin (Protein)


Gene name vagD Uniprot ID C7S9Y5
Locus tag QJP75_RS25875 Protein ID WP_001034046.1
Coordinates 75230..75646 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID V0SR71
Locus tag QJP75_RS25870 Protein ID WP_001261278.1
Coordinates 75003..75233 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP75_RS25845 (70825) 70825..71250 + 426 WP_000422741.1 transposase -
QJP75_RS25850 (71247) 71247..71597 + 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
QJP75_RS25855 (71628) 71628..73241 + 1614 WP_000080195.1 IS66-like element ISEc23 family transposase -
QJP75_RS25860 (73452) 73452..74225 - 774 WP_000905949.1 hypothetical protein -
QJP75_RS25865 (74238) 74238..74738 - 501 WP_000528932.1 HEPN family nuclease -
QJP75_RS25870 (75003) 75003..75233 + 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QJP75_RS25875 (75230) 75230..75646 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin Toxin
QJP75_RS25880 (75691) 75691..79485 - 3795 WP_001144732.1 hypothetical protein -
QJP75_RS25885 (79866) 79866..80096 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin -
QJP75_RS25890 (80093) 80093..80509 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qacE / sul1 / mph(A) / dfrA17 / blaCTX-M-15 / blaOXA-1 / aac(6')-Ib-cr - 1..103076 103076


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14978.31 Da        Isoelectric Point: 6.7113

>T279880 WP_001034046.1 NZ_CP124368:75230-75646 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEAVLKNLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEVKVALRLAGTPIGPNDTAIAGHAIATGAILVTNNVREFERVPGLVLEDWAG

Download         Length: 417 bp

>T279880 NZ_CP124368:75230-75646 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8853.07 Da        Isoelectric Point: 4.6437

>AT279880 WP_001261278.1 NZ_CP124368:75003-75233 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDRIILRPLRPSWSSFLELEKADPGFMTEREDVVCDEGRFNL

Download         Length: 231 bp

>AT279880 NZ_CP124368:75003-75233 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9NXF9

Antitoxin

Source ID Structure
AlphaFold DB V0SR71

References