Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4223480..4224098 Replicon chromosome
Accession NZ_CP124367
Organism Escherichia coli strain AVS0465

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP75_RS20465 Protein ID WP_001291435.1
Coordinates 4223480..4223698 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP75_RS20470 Protein ID WP_000344800.1
Coordinates 4223724..4224098 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP75_RS20430 (4218767) 4218767..4219339 + 573 WP_112023891.1 YbaY family lipoprotein -
QJP75_RS20435 (4219370) 4219370..4219681 - 312 WP_000409908.1 MGMT family protein -
QJP75_RS20445 (4220060) 4220060..4220413 + 354 WP_000878135.1 DUF1428 family protein -
QJP75_RS20450 (4220455) 4220455..4222005 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP75_RS20455 (4222169) 4222169..4222639 - 471 WP_000136192.1 YlaC family protein -
QJP75_RS20460 (4222755) 4222755..4223306 - 552 WP_000102539.1 maltose O-acetyltransferase -
QJP75_RS20465 (4223480) 4223480..4223698 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP75_RS20470 (4223724) 4223724..4224098 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP75_RS20475 (4224644) 4224644..4227793 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP75_RS20480 (4227816) 4227816..4229009 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T279870 WP_001291435.1 NZ_CP124367:c4223698-4223480 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT279870 WP_000344800.1 NZ_CP124367:c4224098-4223724 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References