Detailed information of TA system TA279869

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4038326..4040015
• Replicon: chromosome
• Accession: NZ_CP124367
• Organism: Escherichia coli strain AVS0465

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP75_RS19595
• Protein ID: WP_000365807.1
• Coordinates: 4039095..4040015 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP75_RS19590
• Protein ID: WP_001295795.1
• Coordinates: 4038326..4039108 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP75_RS19585 (4034944)	4034944..4038042	-	3099	WP_000673070.1	type I restriction endonuclease	-
QJP75_RS19590 (4038326)	4038326..4039108	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP75_RS19595 (4039095)	4039095..4040015	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP75_RS19600 (4040180)	4040180..4040956	-	777	WP_000171155.1	site-specific integrase	-
QJP75_RS19605 (4041164)	4041164..4041499	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP75_RS19610 (4041726)	4041726..4041884	-	159	Protein_3830	integrase	-
QJP75_RS19615 (4041933)	4041933..4042118	+	186	WP_000146240.1	hypothetical protein	-
QJP75_RS19620 (4042333)	4042333..4042947	+	615	WP_001019923.1	YagU family protein	-
QJP75_RS19625 (4043018)	4043018..4043184	+	167	Protein_3833	tail fiber assembly protein	-
QJP75_RS19630 (4043196)	4043196..4043525	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP75_RS19635 (4043832)	4043832..4044542	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC / fdeC	4032076..4081007	48931

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T279869 WP_000365807.1 NZ_CP124367:4039095-4040015 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT279869 WP_001295795.1 NZ_CP124367:4038326-4039108 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0